Objective:To investigate the effect of vitamin E supplementation on oxidative stress in patients with MHD(maintenance hemodialysis).Methods:58 patients with MHD and 20 healthy volunteers were involved in this study.The patients were administered 400mg/d of vitamin E for 6 weeks.The plasma levels of oxidative parameters including vitamin E(VitE)

malondialdehyde(MDA)

advanced oxidation protein product(AOPP)

superoxide dismutase(SOD)

activity of glutathione peroxidase(GSH-PX) were measured at the initial and the end of VitE supplementation respectively.Results:Plasma levels of AOPP and MDA(187.27±54.9μmol/L vs99.05±26.2μmol/L

7.74±2.17nmol/ml vs3.06±1.70nmol/ml)were significantly higher in patients with MHD compared with healthy controls(P<0.01).VitE concentration and GSH-PX and SOD activities(3.27±1.36μg/ml vs6.58±1.44μg/ml

74.42±27.46μmol/L vs127.27±25.88μmol/L?70.88±14.74U/ml vs114.67±24.65U/ml) in MHD patients were significantly lower than those in controls respectively.400mg/d of VitE supplementation decreased the plasma levels of AOPP(143.41±33.7μmol/L vs187.27±54.9μmol/L)

MDA(5.19±2.85nmol/ml vs7.74±2.17nmol/ml)CRP(3.49±1.34mg/L vs4.71±1.81mg/L)(P<0.01)

the levels of VitE(5.49±2.06μg/ml vs3.27±1.36μg/ml)

SOD(108.30±22.95U/ml vs70.88±14.74U/ml)

GSH-PX(91.56±14.49μmol/L vs74.42±27.46μmol/L)were increased(P<0.01).Conclusion:There are oxidative stress in patients with MHD

400mg/d of VitE ameliorates oxidative stress without apparent side effect.