Objective:To investigate whether or not theγ-aminobutyric acid(GABA)receptor subtype B genes are associated with idiopathic generalize epilepsy(IGE).Methods:three single nucleotide polymorphisms(SNPs)which loci nearly exon 7 was used as genetic markers.Both case-control study as well as based on Bi-PASA technique were used in 110 with IGE and 110 controls to conduct association analysis.Results:The allele frequencies of these SNPs in Chinese normal population are in good agreement with Hardy-Weinberg equilibrium.The heterozygosity of SNP rs3025627 and rs3025628 and rs29220 are 0.412 and 0.426 and 0.412 respectively.The allele of frequency of heterozygote type of the mutation type of TT in rs3025627 are higher in IGE patients than those in normal controls(P<0.05).Conclusions:All of these SNP rs29220 and rs3025627 and rs3025628 are good genetic markers.The rs3025627 are associated with IGE

but need more samples.All of these SNP rs29220 and rs3025627 and rs3025628 are good genetic markers.