Objective:To detect the relation of peroxisome proliferators actived receptor γ(PPARγ)in the hepatic tissue of chronic hepatitis B and explore its significance.Methods:The protein and mRNA expression of PPARγ was detected by means of immunohistochemistry and semi-quantitative RT-PCR in cases of hepatic fibrosis staging S0-S4 of chronic hepatitis B and cases of hepatic hemangioma.The average of A values was obtained by image analysis.Results:There was not obvious correlation between PPARγ level and the hepatic activity index.Positive staining of PPARγ was observed in all of the human liver tissues.The expression of PPARγin tissues of staging S0 and normal liver was stronger than that in tissues of staging S3 and staging S4(P<0.05).The expression of PPARγ mRNA decreased with hepatic fibrosis extent.Conclusion:The decreased PPARγ expression in tissues of cirrhosis and severe hepatic fibrosis may participate in their pathogenesis.