Objectives:To investigate the prevalence situation and antibiotic resistance of chlamydia trachomatis (CT)

ureaplasma urealyticum(UU) and mycoplasma hominis(MH) in infertile female patient

and to analyze the resistant of mycoplasma to common antibiotics. Methods:The cervical secretion samples from 2186 female infertility and 210 pregnancies women were collected. Then chlamydia trachomatis antigen was detected by immunoassay. Mycoplasma (UU and MH) were isolated and tested antimicrobial susceptibility for 12 kinds of antimicrobial drugs. Results:In the trial group 173 were CT-positive at a rate of 7.9%

and 1102 were positive for the mycoplasmae at a rate of 50.4%

of which 987 were UU infections and 115 were MH infections.The number of CT

UU and MH infections totaled 1275 cases

leading to an overall infection rate of 58.3%. The top three antibiotics for drug sensitivity in the UU

MH and UU+MH cultures were josamycin

minocycline and clarithromycin.The three antibiotics

to which the pathogens were most tolerant

included ofloxacin

norofloxacin and sparfloxacin. Conclusion:The infection rate of chlamydia and mycoplasma in infertility women is obviously higher than normal pregnanted

this shows the fact that chlamydia and mycoplasma infection of genitourinary tract may be one reason of infertility.The sensitivity of mycoplasma to common antibiotics especially to quinolones and macrolides has decreased.