Objectives:To study the change of cytokines in serum of press-overload rats with chronic heart failure(CHF) and the effect of Shengmai injection on cytokines

to uncover the working mechanism of Shengmai injection in treatment of CHF from the standpoint of immunity.Methods:A total of 70 male Wistar rats were divided randomly into sham-operation group(20 rats) and model group(50 rats)

and sham-abdominal aortic stenosis operation and abdominal aortic stenosis operation were given respectively.After 8 weeks

10 rats of each group were randomly chosen to detect hemodynamics parameter.If the results showed the construction of the CHF model was successful

the rest rats of model group were divided randomly into control group and ShengMai group.The rats of sham-operation group and control group were given saline celiac injection

and the rats of ShengMai group were given ShengMai Injection celiac injection.After 4 weeks

hemodynamics parameter and serum concentrations of tumor necrosis factor-α(TNF-α)

interleukin-1β(IL-1β)

interleukin-6(IL-6) and interleukin-10(IL-10) were detected.Results:The serum concentrations of cytokines in control group were higher than those of sham-operation group(P<0.01)

and the concentrations of ShengMai group were lower than those of control group(P<0.01).Conclusions:The serum concentrations of cytokines increase abnormally in CHF

and ShengMai Injection could inhibit the change obviously.