Objective:To evaluate the clinical efficacy of posterior transpedicular screw system internal fixation and anterior radical focus debridement with interbody autografting in the treatment of low lumbar and sacrum spinal tuberculosis with kyphosis deformity.Methods:There were 17 cases of low lumbar and sacrum spinal tuberculosis with kyphosis deformity in this series

including 1 case of L3

4 cases of L4

3 cases of L5

3 cases of L3~4

4 cases of L4~5 and 2 cases of L5S1.The mean age was 37 years.All cases received posterior transpedicular screw system internal fixation

anterior radical focus debridement and autografting with iliac bone.Bed rest was for 8 weeks after surgery and no brace was needed.Anti-tuberculosis treatment lasted 12~18 months.Results:The mean period follow-up was 23 months.All patients achieved satisfactory results

and showed successful interboby fusion within 3~6 months.The kyphosis deformity was corrected and the normal low lumbar and sacrum lordosis were maintained without associated complication.All patients had no focus recurrence of tuberculosis.There were no internal implant complications.Conclusion:It is a safe and effective method to treat low lumbar and sacrum spinal tuberculosis with kyphosis deformity by posterior transpedicular screw system internal fixation and anterior radical focus debridement with iliac bone grafting.