Objective:To study the role of selective psychological intervention on peripheral blood T lymphocyte subtypes and emotion in patients with breast cancer. Methods:Randomized-control study method was adopted. Sixty inpatients with breast cancer were divided into intervention group and control group(30 patients in each group). Patients in both groups received routine chemotherapy and health education while the intervention group also received selective psychological intervention. Psychological intervention methods were selected independently and completed daily by patients in intervention group and completion status was also recorded daily on psycho-treatment form by them. Anxiety and depression of both groups were measured and peripheral blood T lymphocyte subtypes were detected pre- and post-treatment. Results:In intervention group CD3+ CD4+ and the ratio of CD4+/CD8+ of T lymphocyte subtypes were higher

while CD8+ was lower after intervention than that before intervention. A significant difference was also observed compared to that of control group(P<0.01). In controlo group

though CD3+ CD4+ and the ratio of CD4+/CD8+ were higher and CD8+ was lower in post-treatment period than that before treatment

there was no significant difference. In intervention group

HAMA HAMD value showed significant difference after intervention than that before intervention and that in control group(P<0.01). In control group HAMA HAMD value showed significant difference after treatment than that before treatment(P<0.05). Conclusion:Selective psychological intervention can enhance the function of peripheral blood T lymphocyte subtypes and decrease anxiety and depression

so as to improve the prognosis of patients with breast cancer during chemotherapy.