Objective:To investigate the biologic reference interval and clinical meaning of laboratory indexs on intrahepatic cholestasis of pregnancy. Methods:506 normal pregnancy women and 358 intrahepatic cholestasis of pregnancy women(ICP) was elected. detected the laboratory indexs of intrahepatic cholestasis of pregnancy:TBA

TB

DB

CG respectively

and 506 normal pregnancy women based on gestational age ware compared

358 ICP women based on the serious degree of the condition ware compared. Results:the content of TBA

TB

DB

CG wasn’t related to gestational age in 506 normal control group

and the biologic reference interval are: TBA

TB

DB

CG.There are obviously difference of the content of TBA、TB、DB、CG between the ICP women and the normal control group(P<0.05). there are significant difference between the mild group and the severe group too. Conclusion:There is an important meaning to setting up the biologic reference interval of laboratory indexs for diagnosing ICP clinically. According to detect the content of TBA

TB

DB

CG we can divide clinical grading on ICP

and can help to judge the disease.