Objective:To investigate the effects of Jiejufushenning on advanced glycation end products(AGEs)in serum and expression of receptor for advanced glycation end products(RAGE) in kidney in diabetic rats.Methods:Diabetic SD rats were induced by injection of streptozotocin

then the diabetic rats were randomly divided into four groups:diabetic control group(group B)

Jiejufushenning group(group C)

aminoguanidine group(group D)

Jiejufushenning and aminoguanidine group(group E)

age-matched norma1 SD rats served as norma1 contro1 group(group A).After 12 weeks of treatment by corresponding intervention

blood glucose

renal function

the quantitation of urine protein of 24 hours(24hPro)and urine creatinine were determined by the normal methods.The levels of AGEs in serum were determined by fluorospectrophotometry

and the expressions of RAGE in kidney were determined by immunohistochemical methods.Results:The levels of blood glucose

urea nitrogen(BUN)

serum creatinine(Scr)and 24hPro in rats of group C

group D and group E were obviously lower than those of group B

but higher than those of group A;The levels of urine creatinine of group C

D and E were obviously higher than that of group B(P<0.05)

but lower than those of group A;the levels of AGEs in serum and expressions of RAGE in kidney in group C

group D and group E were obviously lower than those of group B

and the level of group D was lower than that of group C

and the level of group E was the lowest

but still higher than that of group A.Conclusion:Similar to AG

JJFSN has effect on inhibiting the action of proteinum unenzyme glycosylation

decreasing the production of AGEs in serum and the expression of RAGE in kidney and decreasing blood glucose

24hPro

BUN and Scr;Combination of JJFSN and AG have a significantly cooperated action.