Objective:To investigate the expression

location and significance of aquaporin1(AQP1) in the tissue of amniotic membrane.Methods:Immunohistochemical method was used to examine the expression of aquaporin1 in the tissue of amniotic membrane of 12 normal full-term pregnant women

11 full-term pregnamt woman with oligohydramnios and 9 with polyhydramnios.Result:Aquaporin1 was expressed in cuboidal epithelial cells of amniotic membrane

and mainly in cytoplasm.There was but a little expression of aquaporin1 in fibroblast of amniotic membrane tissue.There was statistically significant difference of the AQP1 expression between oligohydramnios

polyhydramnios and normal full-term pregnancy women integrative optical density in amniotic membrane tissue

respectively(P<0.05).Conclusion:AQP1 is expressed in cytoplasm of amniotic membrane tissue of human

and it may play a critical role in the process of water-transference.This study provides a molecular biological basis for the study the on molecular mechanism of amniotic fluid transport

and a new thinking for treating abnormal capacity for amniotic fluid.