Objective:To investigate the role of iron ions released by metabolism products of haemoglobin after intracerebral hemorrhage(ICH) in the injury of surrounding brain parenchyma and the influence of intervention by deferoxamine(DFO). Methods:Sprague-Dawley rats were randomly divided into the sham operation groups、intracebral hemorrhage(ICH) groups and deferoxamine groups

and received infusion of autologous blood. Evaluation on neurological function

brain water content

the permability of blood brain barrier

S100B proteins

neuron-specific-enolas(NSE) and the influence of intervention by deferoxamine were detected at different time points after operation. Results:Compared with the sham operation groups

the rats of ICH groups had significantly neurological disorder and the increase of brain water content surrounding brain parenchyma

the permeability of blood brain barrier

S100B protein and NSE of blood serum. The rats of DFO groups had the same trend with the rats of ICH groups in all kinds of observed items but neurological function scores test

brain water content surrounding brain parenchyma

the permeability blood brain barrier

S100B protein and NSE of blood serum were lower than those of ICH groups. Conclusion:The abnormal accumulation of iron ions participates the injury of brain tissue surrounding brain parenchyma after ICH and deferoxamine has the protective role for the injury.