Objective:To investigate the effects and the therapeutic mechanism of Fu Fang Tang Yang of You(FTY)on wound healing and reducing the proliferation scar of deep partial thinkness nurn in rats.Method 120 kun-ming rats were employed as the model.Deep partial thinkness burn wound(s3 cm2 per wound)were made on the back of each rat by 108℃steam.The wound rats were divided into five groups.Four groups underwen(tgroupA

B

C

D)local treatment with FTY

rhEGF

Sulfadiazine silvercream and Vegetable oil

respectively.The control group E was localy treatment with applied the normal saline.Each wound area was calculated by dry/wet weight at 8

24

48

72 hafterinjury.Histological examination:Determination of TGF-β1

typeofcollagenⅠ

Ⅲwith immunohistochemistry.Expression of MMP-1

TIMP-1 were testd by in situ hybridiz-ation and image analgsis at 3

7

14 past-burn days.The apoptosis index was exmined by TUNEL technique.Results:Treatment with FTY could protect the remains of cells and tissues in wound

alleviate inflammatory response

decrease the level of tissues edema

reduce the formation of proliferation scars and accelerate the process of wound healing.Conclusion.FTY could promote the wound healing of deep partial thinkness burn with less scar formation.