Objective:To explore the diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer.Methods:Using pathological examination

or at least one-year clinical follow-up results for the gold standard

we divided patients with liver disease into three two groups:primary liver cancer group

benign liver disease group and normal group

using protein chip technology to detect the measurement serum tumor markers.Results:CA199

CEA

CA242

FER

AFP

CAl25 and CA153 were significantly higher in PHC group than those in benign liver disease group and normal group(P<0.05).Logistic regression excluding FER

from the other six indicators for the diagnosis of PHC model:Logit P=1.357 +0.851 CA199 +1.164 CEA +2.573 CA242 +3.241 AFP +2.647 CAl25 +2.846 CA153.Six tumor markers detected separately

the AUC of AFP is the largest(P<0.05);Combined measure of six tumor markers has greater AUC than the single tumor marker test(P<0.05).Conclusion:Combined CA199

CEA

CA242

AFP

CAl25 and CA153 is the optimum combination for early diagnosis of primary liver cancer

it has a high clinical value.