Objective:To study the clinical characteristics and treatment of thrombotic microangiopathy(TMA)

to improve recognition of TMA.Method:Types

clinical and laboratory characteristics

treatment and prognoses of 12 patients with thrombotic microangiopathy admitted to our hospital between October 2004 and December 2007 were analyzed retrospective1y.Result:The clinical manifestations were characterized by microangiopathic hemolytic anemia(12/12)

thrombocytopenia(12/12)

elevated serum LDH value(12/12)

and renal lesion(12/12)

fever(5/12)

and neurological abnormalities or mental disorders(7/12).3 patients were treated by plasma exchange therapy.1 patient fully recovered

4 patients took a turn for the better

and 7 patients died.Conclusion:TMA is a kind of severe acute syndrome with complicated pathenogenesis and high mortality.Management should depend on the type of TMA in order to improve curative efficacy and reduce mortality.