Objective:To investigate the efficiency

safety and immune mechanism of only house dust mite allergen vaccine for the treatment of perennial allergic rhinitis patients.Methods:30 patients with perennial allergic rhinitis were selected

18 of them were strong positive to dermatophagoides pteronyssinus(group A) and the other 12 patients were strong 3positive to pollen and fungus and et al(group B).The symptom scores and efficiency and the levels of serum IL-4

IL-10

IFN-γ

TGF-β1

and sIgE before and after the allergen-specific immunotherapy in the group of 30 patients were compared with the controlled one with 20 healthy people.Results:1.Among the thirty patients with perennial allergic rhinitis after the treatment

the total effective rate is 83.33%

the markedly effective rate is 60.0%

and the ineffective rate is 6.0%.The patients were treated by the subcutaneous injection for 990 times.The number of the patients who got systemic side-effects was 1 with twice occuring in total

the incidence is 0.1%(2/990);The number of local side-effects were 14 cases with 14 times occuring in total

the incidence is 1.4%(14/990)

but both the local and systemic side-effects were slight.2.The symptom scores of the 30 patients was(4.20±2.21) after therapy

the difference was statistically significant(P<0.01) compared with the former therapy.The levels of IL-4

IL-10 after the treatment was significantly lower than that of pre-treatment

but still higher than the healthy controlled group(P<0.01)

while the levels of IFN-γ

TGF-β1 after the treatment is obviously higher than that of pre-treatment

but still lower than the healthy controlled group(P<0.01).Comparing the level of sIgE in post-treatment with that in pre-treatment

there was a significant difference between them by statistics evaluation(P<0.01).3.The symptom scores of group A after treatment was(4.12±2.11);that of group B was(4.56±2.30)

There was no significant difference in statistics(P>0.05).There was no statistically significant difference in the levels of IL-4

IL-10

IFN-γ

TGF-β1 and sIgE between group A and group B(P>0.05).Conclution:The NHD house can modulate a imbalanced status of Th1/Th2 cells

Some common antigens are contained in both the dermatophagoides pteronyssinus and other allergens:pollen

fungus

et al

which are able to combine with the specific antibodies in serum.This study provides a theoretical basis for the allergen-specific immunotherapy for allergic rhinitis.