Objective:To investigate the value of urine trace protein in early evaluation of the hypoxic ischemic encephalopathy(HIE) combined with renal injury and the relation with HIE severity.Methods:47 cases of full-term HIE neonate were tested of urineβ2-MG (β2-M)

urine albumin(Alb)

serum Cr and BUN within three days postnatal

each case’s clinical grading was assessed in 7 days postnatal

and 13 healthy neonate in the same period were randomly chosen as control group.Those index were observed and compared between test and control groups

correlation analysis was also carried out.Results:The urineβ2-M and Alb in HIE group were significantly higher compared with control group in three days postnata(lP<0.01).With increase of clinical severity

urineβ2-M and Alb gradually increased(P<0.05).Urineβ2-M and Alb in HIE group were positive correlated(r=0.580 4

P<0.05).The abnormal rate of urineβ2-M

Alb was significant higher than serum Cr

BUN(P<0.05).Conclusions:on the base of clinical manifestation of asphyxiated newborns

measurement of urineβ2-Mand Alb in 3 days postnatal was valuable in early evaluation of the HIE combined with renal injury and distinction of the clinical severity.