Objective:To study the pathology

therapy and prevention of the chronic rejection after rat renal transplantation by establishing a simple and feasible allograft nephropathy model.Methods:We used Fisher rats as donors and Lewis rats as recipients.After the left kidney of the donors was removed

the inferiorvena of the donor was anastomosed end-to-end with the left renal vein of the recipient

and the donor’s abdominal aorta was anastomosed end-to-side with that of the recipient with the unaided eyes to carry out renal allograft in prime position.The recipients were given ciclosporin oral solution10 mg/(kg.d)by gavage for 10 days after transplantation

and the pathological changes of the recipient’s transplant kidney would be respectively observed after 4 weeks.Results:The renal allograft in prime position were finished within 2.5 hours

and the achievement ratio was 97.5%.The pathological changes of the transplanted kidney began to appear 4 weeks after transplantation then the chronic rejection could be seen after 12 weeks.Conclusion:This method was simple and direct-viewing

and reduced microsurgery equipment

which successfully established rat renal transplantation model of chronic allograft nephropathy.