Objective:To investigate the profile of the distribution and antibiotic resistances of clinic pathogenic microorganism isolated from 2004 to 2007.Methods:The microorganisms were isolated from clinical samples according to the guides of standard operation protoco1.Identification and antibiotic sensitivity tests were done by Vitek2 and ATB Express system.Results:A total of 10 700 bacteria were isolated

most of which are gram-negative rods.The dynamic analysis of the bacteria distribution showed that infections caused by gram positive coccus exhibited a decreasing tendency

while the infections caused by the P aeruginosa were increasing significantly.The dynamic analysis of antibiotic resistance showed that E coli

K pneumoniae

A baumanii

P aeruginosa were totally sensitive to Imipenem

Meropenem

Amikacin

Piperacillin-tazobactam.Vancomycin

Teicoplanin

Nitrofurantoin exhibited strong anti-bacterial activities against Staphylococcus spp and Enterococcus spp.The dynamic analysis results indicated that the resistance rates to carbapenem in P aeruginosa and A baumanii were increasing sharply.Conclusion:The major clinical pathogenic microorganisms in our hospital were Gram negative rods.Isolating rate of P aeruginosa showed an obviously increasing tendency.The antibiogram profiles of microorganisms have changed obviously

especially the ratios of P aeruginosa and A baumanii that are resistant to carbapenem rose significantly

which suggested the two kinds of organisms were in prevalence in our hospital especially in ICU words.