Objective:To explore the expression of LOX-1(lectin like oxidizeol low density lipoprotein receptor-1

LOX-1) in aorta of atherosclerotic rabbits and modulating the effect of fluvastatin and Shexiang baoxin pill on the gene and protein expression of LOX-1. Methods:Tirty-two New Zealand white rabbits were randomly divided into four groups: hypercholesterol diet group (fed mth high cholesterol diet)

hypercholesterol diet plus Fhevastatin group(fed with high cholesterol diet plus Fhe vastain 25mgl kgld).hypercholesterol diet plus shexiang Bao xin Pill group (fed with high cholesterol diet plus shegxiang Baoxinpill 25mgl kgld).normal diet gwup(fed mith regnlar chow)

the protein expression of LOX-1 in aorta of rabbits were examined by immunohistochemsthy

the gene expresswin of LOX-1 in aorte of rabbits were examined by R7-PCK. Results:hypercholesterol diet group(fed with high cholesterol diet)

hypercholesterol diet plus fluvastatin group(fed with high cholesterol diet plus Fluvastatin 25mg/kg·d)

hypercholesterol diet plus Shexiang baoxin pill group(fed with high cholesterol diet plus Shexiang Baoxin Pill 25mg/kg·d)

normal diet group(fed with regular chow)

the protein expression of LOX-1 in aorta of rabbits were examined by immunohistochemistry

the gene expression of LOX-1 in aorta of rabbits were examined by RT-PCR. Conclusion:LOX-1 was expressed in rabbit aorta of hypercholesterol diet group and two treatment groups

expression of LOX-1 in two treatment groups both significantly reduced compared with hypercholesterol diet group(P<0.05). Conclusion:The gene and protein expression levels of LOX-1 in aorta of atherosclerotic rabbits significantly increased in hypercholesterol diet group

and fluvastatin and Shexiang baoxin pill could strongly inhibit LOX-1 expression in aorta of atherosclerotic rabbits

which may play an important role in prevention of atherosclerosis.