凋亡相关基因livin及cyclin B1在乳腺癌中的表达及意义

王勇军

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凋亡相关基因livin及cyclin B1在乳腺癌中的表达及意义

基础研究 | 更新时间：2024-01-17

- 凋亡相关基因livin及cyclin B1在乳腺癌中的表达及意义
- The overexpression of cyclin B1 and livin in breast carcinoma and its clinical significance
- 重庆医科大学学报 2009年34卷第5期页码：575-577
- 作者机构：
  
  中南大学湘雅二医院输血科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R737.9
- 纸质出版日期：2009，
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[1]王勇军.凋亡相关基因livin及cyclin B1在乳腺癌中的表达及意义[J].重庆医科大学学报,2009,34(05):575-577.

WANG Yong-jun. The overexpression of cyclin B1 and livin in breast carcinoma and its clinical significance[J]. Journal of Chongqing Medical University, 2009,34(5):575-577.
[1]王勇军.凋亡相关基因livin及cyclin B1在乳腺癌中的表达及意义[J].重庆医科大学学报,2009,34(05):575-577. DOI：

WANG Yong-jun. The overexpression of cyclin B1 and livin in breast carcinoma and its clinical significance[J]. Journal of Chongqing Medical University, 2009,34(5):575-577. DOI：

摘要

目的:探讨livin在乳腺癌组织中的表达情况及其与细胞周期素B1（cyclin B1）的关系;方法:应用免疫组织化学方法检测Livin和cyclin B1在57例乳腺癌和10例正常乳腺组织中的表达情况

并分析livin和cyclin B1与临床病理学特征的关系。结果:Livin和cyclin B1蛋白在乳腺癌阳性表达率分别为77.2%（44/57）和68.4%（39/57）

两者的表达呈正相关性（γ=0.701

P<0.001）;Livin的表达与淋巴结转移、年龄、临床分期、肿瘤大小未见显著相关性

cyclin B1的表达与淋巴结转移有显著相关性

而与年龄、临床分期、肿瘤大小未见明显相关性。结论:Livin和cyclin B1在乳腺癌组织中表达上调

提示其可能在乳腺癌发生、发展中起重要促进作用

cyclin B1和淋巴结转移的密切关系表明它的高表达可能反映患者较差的预后。

Abstract

Objective:To study the expression of livin and its correlation with cyclin B1 in breast cancer.Methods:The expressions of livin and cyclin B1 in breast cancer paraffin embedded specimens were detected by immunohistochemical technique.The relationship between livin and cyclin B1 and clinicopathological characteristics was analyzed.Results:The rates of positive expression of livin and cyclin B1 protein in breast cancer were 77.2%and 68.4%

respectively

and the correlation was psitive(γ=0.701

P<0.001).The significant correlation of cyclin B1 with lymphnode metastasis expression was found in breast cancer.Conclusions:Our findings suggest that upregulated expression of livin and cyclin B1 proteins may play an important role in the development of breast cancer.The relationship between cyclin B1 and lymphnode metastasis expression indicates that higher cyclin B1 expression may imply patient’s poor prognosis.

关键词

乳腺癌细胞周期素B1livin

Keywords

breast carcinomaCyclin B1livin

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