Objective:To investigate pharmacodynamics and safety of clobetasol propionate(CP)liposomes on guinea pigs with chronic dermatitis-eczema.Methods:Right ears of guinea pigs were repeatedly challenged with a small dose of dinitrochlorobenzene(DNCB)for the establishment of model of chronic dermatitis-eczema.The curative effect of CP liposomes was evaluated by cellular infiltrates in dermis and ear swelling thickening.Guinea pigs were given CP liposomes and CP cream on the right abdominal once a day for eight weeks

and the epidermal cell layers was calculated and compared.Results:CP liposomes could effectively reduce the number of cellular infiltrates in dermis and ear swelling thickening.This preparation for the application of eight weeks did not cause reduction of epidermal cells layers. Conclusion:CP liposomes is more effective on guinea pigs model of chronic dermatitis-eczema with less side effects.