WANG Yuan-yuan, et al. Expression and significance of chemokine’s receptor CXCR7/RDC1 in human breast carcinoma cells[J]. Journal of Chongqing Medical University, 2009,34(10):1344-1347.
WANG Yuan-yuan, et al. Expression and significance of chemokine’s receptor CXCR7/RDC1 in human breast carcinoma cells[J]. Journal of Chongqing Medical University, 2009,34(10):1344-1347.DOI:
Objective:To investigate the expression and significance of CXCR7/RDC1 in human breast carcinoma cells.Methods: The mRNA and protein expressions of CXCR7 in human breast cancer cells(MCF-7
ZR-75-30
MDA-MB-435S
MDA-MB-453
MDA-MB-231
and HBL-100) were detected with the application of RT-PCR and Western-Blot
respectively.Results: The expression levels of CXCR7 varied significantly among six cell lines.CXCR7 mRNA can be detected in all of the six breast cancer cell lines
and CXCR7 protein expression was statistically prominent in ER positive cell lines and couldn’t be detected in MDA-MB-231 breast cancer cell.Conclusion: CXCR7/RDC1 may play a key role in occurrence