Objective:To study the mechanism of apoptosis in hippocampus of the rats with disorder of cortical developments.Methods:The Rats with disorder of cortical developments were established by carmustine(BUCN).AT P0

P15

P30

P45

P60

the number of apoptosis cell and expression of Bax and Bcl-2 in hippocampus were detected by TUNEL

immunohistochemistry method and RT-PCR;then the detected outcomes were analyzed by computer micrograph analysis system in control group and model group.Results:At P15

P30

P45

P60

the numbers of apoptosis

Bax

Bcl-2 masculine cell and bcl-2 MRNA

bax MRNA in hippocampus in the model group were more than those in the control group.The ratio of Bax/Bcl-2 in model group was significantly higher than those in the control group(P<0.05)

but at P0

they were not different.Conclusion:Apoptosis exist notably in hippocampus of rat with disorder of cortical develop-ments.bcl-2 and bax probably play a role in apoptosis.Apoptosis may be associated with the pathogenesis of epilepsy or intractable epilepsy.