Objective:To investigate the efficacy of low-dose thyroid hormone treatment and the change in levels of thyroid hormone in patients with chronic kidney disease. Methods: 92 children with chronic kidney disease were randomly divided into thyroxine treatment group and control group

with 46 children in each group. All patients received conventional treatment

the treatment group served with additional Levothyroxine of 25 ~ 50μg/d. At least 1 month follow-up was taken to compare the clinical efficacy

RIA detection level of thyroxine. Results: In control group

urinary protein

urine occult blood

Hb and albumin showed no changes at 1w-4w after therapy

and the treatment group also showed this trend. There were no difference between two groups. However

1 week after treatment

SCr and BUN began to decline

till 4th week(P <0.05). Thyroxine and the treatment group and control group over the same period compared to 1 week after treatment and after the decline in SCr and BUN more obvious and continuing to 4 weeks(P <0.05). To thyroid function enhanced in patients in the treatment group at 1 week after treatment (P<0.05)

this trend is maintained up to 4 weeks after treatment;and 1 week after treatment

thyroid function in the treatment group with the same period was improved compared to the control group(P <0.05). FT3 and SCr for all patients showed a negative correlation between the concentration. The correlation coefficient was -0.71 (t = 6.147

P = 0.012). Conclusion: Small dose of thyroid hormone treatment have a good role in the treatment for children with chronic kidney disease. The efficacy of thyroid hormone levels can be used as an indicator for therapy and evaluation for prognosis.