Objective:To evaluate the studies about expression of HIF-1αin colorectal tumor with meta-analysis.Methods: Search was conducted on the following electronic databases:Chinese Bio-medicine Database

Medline

Embase to identify all the relevant case-control trials.Statistical analysis was performed with RevMan4.2 to investigate heterogeneity. The studies were combined and the publication bias was evaluated. Results: Totally 11 studies were recruited.Compared with normal tissue

colorectal cancer and colorectal adenoma showed a significantly higher expression of hif-1α(P<0.05)

the pooled OR and 95%CI were 19.29[6.19

60.09]and 8.60[3.60

20.56] respectively. Compared with colorectal adenoma

colorectal cancer showed no significantly higher expression of hif-1α(P>0.05)

the pooled OR and 95%CI was 2.20[0.98

4.97]. Conclusion:The expression of HIF-1α exists in the whole process of colorectal carcinoma. There is a significantly higher expression of hif-1αin colorectal cancer and colorectal adenoma than that in non-neoplasm colorectal mucosa

and no difference is found between colorectal cancer and colorectal adenoma.