初诊T2DM伴肥胖患者血浆Chemerin水平升高

庞久高; 朱伟; 杨刚毅; 刘颖; 李伶; 陈文雯

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初诊T2DM伴肥胖患者血浆Chemerin水平升高

基础研究 | 更新时间：2024-01-17

- 初诊T2DM伴肥胖患者血浆Chemerin水平升高
- The lever of plasma chemerin increased in newly diagnosed type 2 diabetes mellitus obese patients
- 重庆医科大学学报 2009年34卷第10期页码：1309-1312
- 作者机构：
  
  1. 重庆医科大学附属第二医院内分泌实验室
  2. 重庆医科大学附属第二医院内分泌科
  3. 重庆医科大学检验系临床生化教研室
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（编号:30771037和30370671）;国家教委春晖计划资助项目（编号:2003-56）
- DOI：
  中图分类号： R587.1;R589.2
- 纸质出版日期：2009，
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[1]庞久高,朱伟,杨刚毅,刘颖,李伶,陈文雯.初诊T2DM伴肥胖患者血浆Chemerin水平升高[J].重庆医科大学学报,2009,34(10):1309-1312.

PANG Jiu-gao, et al. The lever of plasma chemerin increased in newly diagnosed type 2 diabetes mellitus obese patients[J]. Journal of Chongqing Medical University, 2009,34(10):1309-1312.
[1]庞久高,朱伟,杨刚毅,刘颖,李伶,陈文雯.初诊T2DM伴肥胖患者血浆Chemerin水平升高[J].重庆医科大学学报,2009,34(10):1309-1312. DOI：

PANG Jiu-gao, et al. The lever of plasma chemerin increased in newly diagnosed type 2 diabetes mellitus obese patients[J]. Journal of Chongqing Medical University, 2009,34(10):1309-1312. DOI：

摘要

目的:探讨初诊2型糖尿病（Type2diabetics

T2DM）伴肥胖患者血浆Chemerin水平变化及其与体重指数（Bodymass index

BMI）、腰臀比（Waist hip ratio

WHR）、血脂、血糖、血浆胰岛素水平等的关系。方法:采用酶联免疫法测定了初诊T2DM非肥胖患者（Type 2 diabeics not with obesity

T2DM-nonob）、初诊T2DM伴肥胖患者（Type 2 diabetics with obesity

T2DM-ob）、正常糖耐量非肥胖者（Normal glucose tolerance not with obesity controls

NGT-nonob）和正常糖耐量肥胖者（Normal glucose tolerance with obesity controls

NGT-ob）血浆Chemerin水平

并分析了血浆Chemerin水平与BMI、WHR、血脂、血糖、血浆胰岛素、胰岛素抵抗指数（HOMA insulin resistance index

HOMA-IR）等的关系。结果:T2DM伴肥胖组血浆Chemerin水平明显高于T2DM不伴肥胖组和NGT不伴肥胖组（[73.3±9.5）μg/L vs（65.3±13.4）μg/L vs（58.5±19.5）μg/L

P<0.01和P<0.05)]

NGT伴肥胖对照组血浆Chemerin水平明显高于NGT不伴肥胖对照组（[72.0±15.2）μg/L vs（58.5±19.5）μg/L

P<0.05];胰岛素抵抗组（Insulin resi-tance

IR）Chemerin水平明显高于胰岛素敏感组（Insulin sensitive

IS）（[70.7±9.6）μg/L vs（61.7±19.1）μg/L

P<0.01]。多元回归分析结果表明WHR、体内脂肪百分比（Visceral fat%

FAT%）分别是影响血浆Chemerin水平的独立相关因素。结论:血浆Chemerin水平的改变与肥胖相关因素和胰岛素抵抗等有关

并可能参与了肥胖、胰岛素抵抗和T2DM的发生和发展。

Abstract

Objective: To investigate the changes of plasma Chemerin level and the relationship between plasma Chemerin and body mass index(BMI)

waist hip ratio(WHR)

blood lipids

blood glucose

plasma insulin levels as well as other factors in newly diagnosed type 2 diabetic patients(T2DM) with obesity.Methods: Plasma Chemerin level was assayed by ELISA in the T2DM with obesity(T2DM-ob)

T2DM not with obesity(T2DM-nonob)

normal glucose tolerance controls with obesity(NGT-ob) and normal glucose tolerance controls not with obesity(NGT-nonob).The relationship between plasma Chemerin level and BMI

WHR

blood lipids

plasma glucose

plasma insulin

HOMA-insulin resistance index(HOMA-IR)were also analyzed.Results: Plasma Chemerin levels in T2DM-ob were significantly increased compared with T2DM-nonob and NGT-nonob controls.[(73.3±9.5)μg/L vs(65.3±13.4)μg/L vs(58.5±19.5)μg/L]

P<0.01和P<0.05)]

Plasma Chemerin levels in NGT-ob controls were significantly increased compared with NGT-nonob controls[(72.0±15.2)μg/L vs(58.5±19.5)μg/L

P<0.05];Plasma Chemerin levels in insulin resistant group(IR) were significantly increased compared with insulin sensitive group(IS) [(70.7±9.6) μg/L vs(61.7±19.1)μg/L

P<0.01].Multiple regression analysis showed that WHR

FAT% were independent related factors influencing plasma Chemerin levels.Conclusion:The change of Chemerin level was associated with obesity related factors and insulin resistance

and it may contribute

in part

to the pathogenesis of obesity

insulin resistance and T2DM.

关键词

chemerin糖尿病2型肥胖胰岛素抵抗

Keywords

chemerinDiabetic mellitusType 2obesityinsulin resistance

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