Objective:To investigate the effect of flurbiprofen axetil on the pain after artifical abortion and its mechanism. Methods: A total of 120 ASAⅠ~Ⅱ induced abortion patients were randomly divided into 4 groups(n=30 each). Group F50 was treated with flurbiprofen axetil(50 mg) combined with propofol

Group F75 with flurbiprofen axetil(75 mg) combined with propofol

Group C with blank emulsion combined with propofol and Group K with ketamine combined with propofol.All patients took Misoprostol tablet by mouth 2 hours before artifical abortion

patients of group F50

group F75 and group C were intravenousely injected flurbiprofen axetil or blank emulsion five minutes before propofol

and patients of group K were administered mixed solution of ketamine and propofol. HR

BP

side effect

and pain of VAS score after artifical abortion were recorded. Reslts: Pain of VAS score after artifical abortion in group C and group K were higer than those of group F50 and group F75 at the same time(P<0.05)

pain of VAS score after artifical abortion in group F50 and F75 began to decrease from 15 minutes after operation(P<0.05)

while the pain of VAS score after artifical abortion in group C and group K began to decrease from 30 minutes afeter operation(P<0.05). Conclusion: Flurbiprofen axetil(50 mg and 75 mg) can reduce pain of VAS score after artifical abortion

and the possible mechanism maybe the flurbiprofen axetil inhibit the prostaglandin to release.