Objective:To study the expression of CD44V6 and Ezrin in human non-small cell lung cancer(NSCLC). Methods:CD44V6 and Ezrin were detected by two-step immunohistochemical staining technique in tumor tissues from 65 lung cancer cases and in normal lung tissues from 15 patients with benign disease and analyzed by the lung cancer clinicopathologic characteristics. Results:The positive rate of CD44V6 expression in NSCLC was 69.23%

and no difference was detected in the normal lung tissues.The up regulated of CD44V6 expression was significantly correlated with lymph node metastasis and distant metastasis

but not correlated with pathological type

the degree of differentiation of tissue and clinical stage.The positive incidence of Ezrin expression (72.3%)was significantly lower in lung cancer tissues than that in normal tissues (100%)(P<0.05)

and the down-regulation of Ezrin expression was significantly correlated with lymph node metastasis and distant metastasis

but not correlated with pathological type

the degree of differentiation of tissue. Also

Ezrin expression in lung cancer tended to move from cell membrance to cell plasma. Conclusion:CD44V6 and Ezrin are involved in carcinogenesis.The levels of CD44V6 and Ezrin may be a sensitive predictor for metastasis and prognosis in NSCLC.