Objective:To explore the relation of the abnormal condition of centrosome and p53 genetic mutation of bladder cancer cells

its effect on the onset and progress of the transitional cell carcinoma of bladder because of p53 genetic mutation. Methods: 76 transitional cell carcinoma of bladder were examined.The centrosome was stained by indirect immunofluorescence methods

and the primary antibody was monoclonal antibody against pericentrin.The p53 was stained by SP immunohistochemical methods and the primary antibody was monoclonal antibody against p53.Results: Through statistical analysis

detection of CH or p53 expression was useful in providing prognostic information in bladder cancer. There existed a positive correlated(r=0.707

P<0.01) between the CH and the p53 genetic mutation. Conclusion:CH may be an important middle link of the onset and progress of the transitional cell carcinoma of bladder because of p53 genetic mutation.Study of CH may help to deepen understanding of the mechanism of the tumorigenesis and provide new therapy for tumor in clinic.