Objective:To investigate the effects of three different anesthetic techniques on pere-anesthesia circulation

stree response and post-anesthesia recovery in patients undergoing leparoscopic cholecystectomy(LC).Methods:Sixty-six ASA Ⅰ or Ⅱ patients aged 18 to 60 undergoing selected LC surgery were randomly divied into 3 groups(n=22).The patients in group I were induced and maintained with remifentanil and sevoflurane.The patients in group Ⅱ with fentanil

propofol and isoflurane

while the patients in group Ⅲ with remifentanil and propofol TCI.MAP and HR were measured before induction

before intubation

at 5 min after intubation

1 min and 15 min after the establishmen of CO2 pneumoperitoneum and at the end of operation.Blood cortisol(Cor)and blood glucose(Glu)were measured before induction

after induction 5 min and at the end of operation;Blood interleukin-6(IL-6)was measured before induction and at the end of operation.Postoperative recovery time

Alddret ≥9

the rate of PONV and VAS score were measured on the first postoperative day.Results:There were significant decreases of MAP in group Ⅰ and Ⅱ before intubation(P<0.01).MAP in group Ⅲ increased significantly 1 min after CO2 pneumoperitoneum was established.Blood IL-6 of Group Ⅰ and Ⅲsignificantly increased at the end of operation(P<0.01).Cor and Glu of all three groups were significantly increased at the end of operation compared with those before induction(P<0.01).In anesthesia recovery duration

the times for extubation

recovery and the Aldrete≥9 score were significantly shorter in group Ⅰ and group Ⅲ compared with group Ⅱ(P<0.01).The rate ofPONV and VAS score after operation had no significant differences between either two of the three groups(P > 0.05).Conclusion:The three anesthetic techniques can be used safely on LC operation

anesthesia with remifentanil and sevoflurane

anesthesia with remifentanil and propofol TCI have shorter post-operative recovery time and high quality compared with the anesthesia with fentanil

isoflurane and propofol.LC operation can cause obvious stress response of the body

significant postoperative pain and high rate of PONV

which should be actively dealt with.