Objective: To observe the effect of artemisinin extract on the urinary and digestive system in rabbits.Methods: 32 healthy New Zealand white rabbits were randomly divided into four groups: normal saline group

low dose group

the dose and high-dose groups

10 mg/kg of normal saline

10

100 and 500 mg/kg artemisinin extract were injected into ear vein in rabbits with continuous medication for 12 days.Major changes of biochemical indicators of the liver and kidney were observed each group.The smooth muscle function and histology performance of duodenum and colon and small intestine were observed in each group in vitro.Results:(1) After treatment

in addition to high-dose group with some high value of ALT and AST

no statistically significant changes of ALT

AST

T-BiL

BUN and Cr values were found in the remaining experimental groups(P>0.05).(2)The augment

construction and tension of the duodenum

small intestine and colon smooth muscle movement were increased to the extent in the high dose group and nothing was found in other groups.Conclusion: No obvious adverse effects of artemisinin extract were found on the urinary and digestion system in rabbits and the movement of gastrointestinal function was promoted in the higher dose.