Objective:To investigate the prevalence

antibiotic resistance and risk factors of Acinetobacter Baumannii hospital-acquired pneumonia(ABHAP)in Respiratory Intensive Care Unit(RICU)of our hospital for guidance of clinical prevention and treatment of ABHAP.Methods:Clinical information and results of Antibiotic susceptibility test for all of the patients with hospital-acquired pneumonia(HAP)in RICU of our hospital from May 2007 to October 2008 were collected.Antibiotic resistance and risk factors of ABHAP were analyzed retrospectively.Results:159 patients suffered from HAP.Of which

49 patients had ABHAP and accounted for 30.8% of all cases.Acinetobacter Baumannii was the second commonest pathogen of HAP.The resistance rate of Acinetobacter Baumannii strains to the third generation of Cephalosporin and Fluoroquinolone were over 90%.And the resistance rate to Imipenen was 42.7%.Pan-resistant rate was 23.5%.Univariate analysis showed that APACHEII score ≥20

hospita1ization in RICU ≥2 weeks

invasive mechanical ventilation

invasive mechanical ventilation ≥7 days

trachea intubation or tracheotomy

trachea intubation or tracheotomy≥7 days and broad-spectrum antibiotic therapy≥7 days were associated with BAHAP.Multivariate logistic analysis showed that hospita1ization in RICU≥2 weeks

invasive mechanical ventilation≥7 days

APACHEII score≥20 and broad-spectrum antibiotic therapy ≥7 days were independent risk factors of ABHAP.Conclusions:The present study found high incidence rate

severe drug-resistance and therapeutic difficulties of ABHAP in RICU.Shortening duration of hospitalization and invasive mechanical ventilation

rational use of antibiotics are helpful to prevent and treat ABHAP.