Objective:To investigate the expression and postmortem stability of HSP70 in hippocampus of hemorrhagic shock rat.Methods:105 healthy SD rats were randomly divided into 5 groups:normal group

sham operation group

hemorrhagic shock group

traumatic control group and postmortem stability group.In hemorrhagic shock group and postmortem stability group

rats were submitted by controlled bleeding

with the mean arterial pressure kept around 40mmHg.And in traumatic group

brain contusion was induced by piston impact.After that

the regulation of HSP70 expression in hippocampus of each group was detected by immunohistochemistry technique

and evaluated with image analysis technique and statistic system.Results:One hour after hemorrhagic shock

HSP70 expression in hippocampus was significantly higher in each shock subgroups compared with that in normal group and sham group(P<0.01)

but there was no significant difference in HSP70 expression among each subgroups of postmortem stability group(P>0.05).Conclusion:HSP70 is specifically expressed in hippocampus of hemorrhagic shock rat

and showed nice postmortem stability under the environment of -20℃.