CAI Shuang-shuang, et al. Study on disintegrating method for simvastatin orally disintegrating tablets[J]. Journal of Chongqing Medical University, 2009,34(10):1394-1396.
CAI Shuang-shuang, et al. Study on disintegrating method for simvastatin orally disintegrating tablets[J]. Journal of Chongqing Medical University, 2009,34(10):1394-1396.DOI：
Objective:To evaluate three disintegrating equipments for simvastatin orally disintegrating tablet.Methods: Simvastatin orally disintegrating tablets were prepared by solid-states-dissolution technology
and three disintegrating equipments were used to detect the disintegration of orally disintegrating tablets in vitro
and also the relationship between disintegrating results:in vivo and in vitro was studied.Results:Tube inverted method has good reproducibility
in vivo-in vitro relationship and effective control of particle size
but the results of the other two methods were not so good.Conclusion: Tube inverted method is suitable for testing the disintegration of freeze-dreled orally disintegrating tablets in vitro.
关键词
辛伐他汀口腔崩解片冻干片崩解测定体内外相关性
Keywords
Simvastatin orally disintegrating tabletsFreeze-dried tabletsDisintegration testCorelation in vivo and in vitro
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