Objective:To study the protective effect of Cinnarizine induced by QA and its related mechanism.Methods:Rat models of dysmnesia were made by injecting QA into CA1 districts of hippocampuses with microinjector to explore the protective effect of Cin and its related factors on QA induced impairment of hippocampuses neuron.Results:Compared with control group

in Morris water maze test time of finding the platform under the water surface decreased

and in step-through test the latent period rose.Cin could also decrease the pathological alterations of brain nerve cells in dysmnesia models.The above results indicated that Cin could not only improve the dysmnesia in rat models

but also decreased the pathologic damage in brain tissue.The number of glutaminergic neuron positive nerve cells was increased.Conclusion:Cin could improve the dysmnesia in rat models by mitigating damage in glutaminergic neuron.