超声微泡对大鼠前列腺中药物浓度的影响

魏武然; 张唯力; 戴君勇; 刘颖; 王志刚; 冉海涛

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超声微泡对大鼠前列腺中药物浓度的影响

泌尿外科学专题 | 更新时间：2024-01-17

- 超声微泡对大鼠前列腺中药物浓度的影响
- Experimental study on the influence of ultrasound-mediated microbubble on the medicine concentration in rat prostate
- 重庆医科大学学报 2009年34卷第9期页码：1154-1156
- 作者机构：
  
  1. 重庆医科大学附属第二医院泌尿外科
  2. 重庆医科大学超声影像学研究所
- 作者简介：
- 基金信息：
  
  国家自然科学基金重点项目资助（30430230）
- DOI：
  中图分类号： R697.33
- 纸质出版日期：2009，
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[1]魏武然,张唯力,戴君勇,刘颖,王志刚,冉海涛.超声微泡对大鼠前列腺中药物浓度的影响[J].重庆医科大学学报,2009,34(09):1154-1156.

WEI Wu-ran, et al. Experimental study on the influence of ultrasound-mediated microbubble on the medicine concentration in rat prostate[J]. Journal of Chongqing Medical University, 2009,34(9):1154-1156.
[1]魏武然,张唯力,戴君勇,刘颖,王志刚,冉海涛.超声微泡对大鼠前列腺中药物浓度的影响[J].重庆医科大学学报,2009,34(09):1154-1156. DOI：

WEI Wu-ran, et al. Experimental study on the influence of ultrasound-mediated microbubble on the medicine concentration in rat prostate[J]. Journal of Chongqing Medical University, 2009,34(9):1154-1156. DOI：

摘要

目的:利用超声白蛋白微泡造影剂经一定声压超声辐照后产生的"声孔效应"（Sonoporation）

以及其靶向性来提高前列腺内的药物浓度。方法:选取已建立慢性前列腺炎模型大鼠30只

随机分为对照组

给药组和给药加微泡组。将EA-10原料药以溶媒溶解后注射给药。对照组给予生理盐水

给药组以15mg/kg剂量给药

微泡组以15mg/kg剂量给药

给药后微泡尾静脉注射并用超声基因转染仪前列腺局部间歇辐照2min。照射后取前列腺组织

匀浆后测量组织中EA-10的浓度变化。结果:对照组前列腺组织中没有药物

给药组和给药加微泡组前列腺组织中药物浓度较对照组高（P<0.01）

给药加微泡组前列腺组织中药物浓度较给药组高（P<0.05）。结论:超声白蛋白微泡造影剂的"声孔效应"对于前列腺组织药物浓度的提高有明显的促进作用。

Abstract

Objective:To increase the medicine concentration in rat prostate by the "sound aperture effect" and site-targeted effect of ultrasound-Mediated Microbubble in order to get better therapeutic effect. Methods: 30 1-year-old male Sprague-Dawley rats were castrated and injected estradiol benzoate for 30 days and divided into three groups randomly

model group

treatment group and ultrasound-mediated microbubble group. Model group was treated with sodium chloride

treatment group was treated with EA-10 and ultrasound-mediated microbubble group was given ultrasound-mediated microbubble and EA-10. Concentration of EA-10 in prostate was measured after the prostate was taken and homogenated. Results: Concentration of EA-10 in treatment group as higher than that of in model group(P<0.01). But more EA-10 was measured in ultrasound-mediated microbubble group than in treatment group(P<0.05). Conclusion: Ultrasound-mediated microbubble can markedly promote the increase in the drug concentration in rat prostate.

关键词

舍尼通药物浓度大鼠超声微泡前列腺EA-10

Keywords

CerniltonMedicine concentrationratultrasoundmicrobubbleprostateEA-10

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