Objective:To explore the risk factors for secondary pulmonary fungal infections related to ventilator associated pneumonia(VAP) in order to provide the reference for clinical diagnosis and treatment.Methods:The clinical data of 126 patients with pulmonary fungal infections related to VAP from June 2005 to June 2010 were retrospectively collected.The patients were divided into fungal infection group(56 patients) and non-fungal infection group(70 patients).The risk factors including gender

age

complicated basic diseases

blood sugar

hypoalbuminemia

trachea incision

deep venipuncture

mechanical ventilation time

radiation or chemotherapy

time of using antibiotics

combined use of antibiotics

glucocorticosteroid(immunodepressant)

and APACHEⅡscore were analyzed using the single factor analysis and logistic regression.Results:The single factor analysis showed that age

complicated basic diseases

blood sugar

hypoalbuminemia

mechanical ventilation time

radiation and chemotherapy

time of using antibiotics

combined use of antibiotics

glucocorticosteroid(immunodepressant)

and APACHEⅡscore were significantly correlated.Logistic regression analysis suggested blood sugar

mechanical ventilation time

time of using antibiotics

combined use of antibiotics

glucocorticosteroid(immunodepressant)

and APACHEⅡscore were significantly correlated.Conclusion:Multiple factors affect pulmonary fungus infection

and clinical treatment should be specificly analysed as to the risk factors of older age

mechanical ventilation time

blood sugar

time of using antibiotics

combined of antibiotics

glucocorticosteroid(immunodepressant)

and high APACHEⅡscore.