Objective:To investigate the relationship of expression of ERCC1 and BRCA1 and prognostic in advanced non-small cell lung cancer(NSCLC) of Uygur patients.Methods:The formalin-fixed biopsy speciments of 80 cases of NSCLC Uygur patient from January 2004 to December 2008 are reviewed.We detect the expression of ERCC1 and BRCA1 by immunohistochemical method.Then we analyze the relationship of these two genes and prognostic of the patients.Results:In these 80 cases

positive expression rates of ERCC1 was 38.6%(31/80)

and this gene is no correlation with age

gender

clinical stage and pathology

but is correlation with smoking and PS score.Positive expression rates of BRCA1 was 88.8%(71/80)

and this gene is no correlation with age

gender

smoking

clinical stage and pathology

but is correlation with PS score.The expression of ERCC1 and BRCA1 to median survival weeks is analyzed by Univariate analysis in Kaplan-Meier method

which display the difference is no statistically significant(P>0.05).The negative expression of ERCC1 has longer life than the positive ones

and the difference in survival rate of 1 year is statistically significant(P=0.035).But in overall survival the difference is no statistically significant.Conclusion:The negative expression of ERCC1 could help to predict the prognosis and survival time in advanced non-small cell lung cancer of Uygur patients.The expression of BRCA1 was no statistically significant in NSCLC of Uygur patients temporarily.The result of this study may provide new sight for clinical therapy and prognosis to individual NSCLC Uygur patients.