Objective:To investigate the correlation between N-terminal pro-B-type natriuretic peptide(Nt-proBNP) and left ventricular ejection fraction(LVEF)

determine the predictive value in severe sepsis patients with early myocardial dysfunction

and identify the intervention effect of ulinastatin in sepsis induced myocardial dysfunction.Methods:Forty severe sepsis patients were randomly divided into control group(Group C) and ulinastatin group(Group U)

with 20 patients in each group.Group C accepted early goal directed therapy

and Group U accepted additional therapy of ulinastatin intravenous drop

300

000 units each time

and two times a day for 5 days;then reduced to 100

000 units each time

and two times a day for 2 days.Concentration of plasma Nt-pro BNP and left ventricular ejection fraction were measured at pre-therapy

on the 4th day and the 7th day.Results:Concentration of plasma Nt-pro BNP reached its peak on the 4th day

which was lower in Group U than in Group C

then reduced on the 7th day

which was lower than that at pre-therapy in the two groups

but the difference had statistical significance only in Group U(P<0.05).The level of LVEF was the lowest on the 4th day in the two groups

which was lower in Group C than in Group U;then it increased on the 7th day

and was higher in group U(P<0.05).All patients were divided into two groups according to LVEF.LVEF>50% meant normal cardial function

and otherwise meant abnormal.Concentration of plasma Nt-pro BNP was higher in abnormal group(P<0.05).There was negative correlation between Nt-pro BNP and LVEF.Conclusion:Concentration of Nt-proBNP is negatively correlated with LVEF.It may be used to prognose myocardial function in patients with severe sepsis.Ulinastatin can reduce the concentration of Nt-proBNP and improve myocardial function of severe sepsis patients.