Objective：In order to explore the potential risk factors for urosepsis following endourological treatment of upper urinary stones. Surgical methods include percutaneous nephrolithotomy（PCNL），rigid ureteroscopic lithotripsy，flexible ureteroscopic lithotripsy. Methods：Totally 2 032 patients treated with PCNL，1 781 patients treated with rigid ureteroscopic lithotripsy and 625 patients treated with flexible ureteroscopic lithotripsy were collected from January 2013 to January 2017. Association between different groups was as－sessed by Chi squar to find out the related factors. Then multivariate logistic regression analysis on these related factors was used to further analysis. Results：Multivariate logistic regression analysis showed that urine routine examination（OR95%CI=2.008 to 7.584），urine culture examination（OR95%CI=1.496 to 3.489），stone size（OR95%CI=1.811 to 5.420） were related with urinary sepsis follow－ing PCNL. Urine routine examination（OR95%CI=1.602 to 6.776），urine culture examination（OR95%CI=2.659 to 7.924） were related with urinary sepsis following rigid ureteroscopic lithotripsy. Urine culture examination（OR95%CI=1.739 to 12.770） was related with urosepsis following flexible ureteroscopic lithotripsy. Conlusion：Preoperative urinary tract infection is the most important factor for urosepsis following endourological management of upper urinary stones. In addition，stone size is also one of the important factors for urosepsis after PCNL.