Objective：To evaluate the effect of the collaborative care model on self-care agency and depression in patients with first stroke. Methods：A total of 101 first stroke patients were randomly chosen between January and June of 2016，and randomly assigned into experimental group（52 persons） and control group（49 persons）. The patients in experimental group received collaborative care and the ones in control group only received routine care. After 6 months，the both groups were assessed with the Exercise of Self-care Agency Scale（ESCA） and Self-rating Depression Scale（SDS） to explore the effect of collaborative care on patients’ self-care agency and depression. Results：There was no significant difference in the self-care agency（t=-0.375，P=0.708） and depression（t=-0.258，P=0.797） between the two group before intervention. The self-care agency（t=4.122，P=0.000） and the depression（t=-2.515，P=0.014） of the experimental group were significantly improved compared with those of control group after the intervention，and the self-care agency（t=-2.980，P=0.004），depression（t=10.491，P=0.000） of the experimental group were also significantly improved after intervention. Conclusion：Collaborative care model can significantly improve first stroke patients’ self-care agency and depression.