Metformin,as a classic oral hypoglycemic agent for the treatment of type 2 diabetes,has been shown to have a positive ef-fect on bone mineral metabolism in recent years,but its mechanism of action is very complicated,including inducing osteoblast differ-entiation,reducing the number of osteoclasts,and reversing the apoptosis of osteocytes and osteoblasts directly or indirectly induced by hyperglycemia. This article reviews the research advances in this field.
关键词
二甲双胍骨矿盐代谢2型糖尿病AMP依赖的蛋白激酶晚期糖基化终产物
Keywords
metforminbone mineral metabolismtype 2 diabetesadenosine 5’-monophosphate-activated protein kinaseadvanced glycation end product