Objective：To investigate the accuracy of dynamic blood glucose monitoring system in monitoring blood glucose changes in diabetic patients and the role of psychological nursing intervention. Methods：Totally 190 diabetic patients enrolled in our hospital from February 2014 to April 2016 were selected as the research object and all patients were divided into the control group（n=95） and study group（n=95） according to the random number method. In the control group，the blood glucose monitor was used to monitor the changes of blood glucose and the patients were treated with routine nursing. The patients in the study group were treated with the continuous glucose monitoring system（CGMS） combined with psychological nursing intervention. The accuracy of blood glucose mon－itoring was compared between the two groups，and the influence of different nursing intervention modes on the patients was analyzed. Results：The monitoring accuracy of the study group was higher than that of the control group. The analysis of Clarke EGA index showed that A/B level accounted for 95.8%，higher than 83.2% of control group（ ?字2=8.047，P=0.005）. The control effect of blood glu－cose level in the study group was better than that of the control group and the SAS score（20.4±5.8） and SDS score（19.3±1.5） were significantly lower than those of the control group of SAS score（51.2±10.4） and SDS score（55.7±3.6）（t=25.210，P=0.000；t=90.970，P=0.000）. There were significant differences between the two groups（P<0.05）. Conclusion：CGMS has higher accuracy in de－tecting blood sugar changes in diabetic patients，and psychological nursing intervention can eliminate negative emotions and has posi－tive effects on blood sugar control.