Objective：To explore the influencing factor of pulse wave velocity in patients with maintenance hemodialysis. Methods：Seventy patients with maintenance hemodialysis were selected from blood purification center of the First Affiliated Hospital of Wannan Medical College. The blood pressure of 24 hours was measured by dynamic blood pressure meter. CfPWV was monitored and biochemi－cal markers were measured by biochemical analyzer. CRP，BNP，NTproBNP，Troponin I and Troponin T were measured by enzyme-linked immunosorbent assay（ELISA）. A simple correlation analysis was performed and further linear regression analysis was per－formed. Results：①Levels of cfPWV were positively correlated with age，24SBP，dSBP，nSBP，24PP，dPP，nPP and BNP in patients with maintenance hemodialysis，r=0.304，0.540，0.548，0.506，0.643，0.651，0.595，0.294；P=0.010，0.000，0.000，0.000，0.000，0.000，0.000，0.014，respectively. Levels of cfPWV were negatively correlated with dialysis age，Ca，24HR and nHR in maintenance hemodialysis patients，r=-0.249，-0.252，-0.311，-0.255；P=0.038，0.038，0.006，0.045，respectively. ②Multivariate regression analysis showed that main influencing factors of cfPWV in patients with maintenance hemodialysis were dPP and Ca. Conclusion：Arterial pressure and serum calcium may be influencing factors of pulse wave velocity in patients with maintenance hemodialysis.