Klotho gene is a widely expressed anti-aging gene，with functions of anti-inflammatory，anti-oxidation，anti-apoptosis，etc. In recent years，studies have shown that decreased level of Klotho expression is associated with pathologic progression of diabetes and diabetic nephropathy，which can be improved by overexpressing Klotho or adding exogenous Klotho protein. Moreover，Klotho may have an effect on vasculopathy in patients with T2DM by endothelin-1. Therefore，Klotho may become an important therapeutic target for diabetes.