Objective：To investigate the influence of different bonding ways and appliances on periodontal health in adolescent male patients with fixed treatment. Methods：One hundred and twenty adolescent male patients with fixed treatment were enrolled. The me－dian age of patients was 12.9 years old（ranged from 11 to 16）. The patients were divided into four groups equally：conventional brackets with direct bonding group，conventional brackets with indirect bonding group，self-ligating brackets with direct bonding group and self-ligating brackets with indirect bonding group. The bleeding index（BI），probing depth（PD） and attachment loss（AL） of patients were examined before fixed treatment（T0） and one month（T1），two months（T2） and three months（T3） after the treatment，respectively. Results：The BI and PD of patients markedly increased over time after fixed treatment（P=0.000）. The BI and PD were not significantly different between patients with conventional brackets and patients with self-ligating brackets（P>0.05）. The BI of canines in patients with self-ligating brackets with direct bonding was lower than those with indirect bonding（P=0.001），and the BI of first mo－lars，lateral incisors and central incisors in the two groups were not statistically different（P>0.008）. The BI of canines in pa－tients with conventional brackets with direct bonding was lower than those with indirect bonding（P=0.000），and the BI of first molars，lateral incisors and central incisors in the two groups were not statistically different（P>0.008）. Meanwhile there was no statistical difference in PD between the two groups（P>0.05）. Conclusion：The BI and PD of patients increase over time after fixed treatment. The type of brackets is not the important factor for periodontal health in adolescent male patients with fixed treatment. Compared with indirect bonding，direct bonding is better for periodontal health in adolescent male patients with fixed treatment.