The herb pairs of coptis and evodia first appeared in Song dynasty. One is bitter while the other one is pungent，one falls while the other rises，and this compatibility has an obvious pharmacological effects in digestive system. Modern studies show that the herb pairs of coptis and evodia has a certain anti-gastric cancer and other anti-tumor activity，but its efficient material base and cooperation mechanism remains unclear. This article summarizes literature within ten years，with detailed description about the anti-tumor mechanism and the mechanism of synergism of the couple and its main monomers. At the same time，the research finds out the commonality of the drug in the treatment of tumor and type 2 diabetes mellitus target pathway. This review provides a new idea for the clinical application of berberine and evodiamine in the treatment of tumors and type 2 diabetes mellitus，and elucidates the mecha－nism of the interaction of berberine and evodiamine in anti-tumor from the perspective of signal pathway，which lays a theoretical foundation for anti-tumor in the clinical.