Objective：To understand the implementation effects on the quality of life of the adolescent leukemia children in chemotherapy under the humanistic nursing management model，improve the prognosis and the quality of life. Methods：As a case-control study，97 adolescent children receiving chemotherapy from the Affiliated Children’s Hospital of a Medical University were enrolled. The changes of the quality of life before and after the intervention of holistic nursing management model were compared. The current quality of life and the problems of the adolescent leukemia children in chemotherapy was investigated before intervention through the survey using self-designed scale（the quality of life scale for leukemia children of different ages） combined with the semi-structured interviews on children’s quality of life. The holistic nursing management model is applied according to the results and all the indicators of the quality of life were examined after 3 months. Results：The total score and scores in all fields of the leukemia children before and after the intervention were significantly im－proved（P<0.05）. Among them，the mental emotion and social interaction improved most evidently. And there is no obvious difference（P<0.05） before and after the intervention in the school performance in all fields. And there was no obvious dif－ference in parts of the factors（P>0.05） including the weaker performance of the leukemia children in the school activity than the peers，the absence from class due to the illness，the great help of the medical insurance in relieving the economical burden. Conclusion：The holistic nursing management model can re－lieve anxiety and depression in children with leukemia chemotherapy，significantly improve the quality of life and let leukemia chil－dren return to society as soon as possible.