Objective：To discuss on the causes and treatment of epidural hematoma in the adjacent area and distant location during the resection of giant meningioma by the sickle of the sickle. Methods：The clinical data of 5 patients with postoperative epidural hematoma who underwent giant meningioma resection in the department of neurosurgery of First Affiliated Hospital of Chongqing Medical University from May 2012 to June 2017 were retrospectively analyzed. Results：Bulging and high pressure appeared during the brain surgery. High pressure was still existed after the surgery. Intraoperative cranial ultrasound indicated bleeding in the surgery area or adjacent area. Emergency cranial CT showed the immediate postoperative epidural hematoma formation. The epidural hematoma was confirmed by the surgery （one case of bleeding in the distant location，and the other 4 cases of bleeding in the vicinity of the op－eration area or accompanied by a distant hemorrhage）. Conclusion：In the resection of the giant meningioma beside the sickle of the sinus，the incidence of epidural hemorrhage in the adjacent area and the distant location is low，but it is very dangerous. If it can be found and treated in time，the prognosis is good. If there are intraoperative brain swelling，high brain pressure or high brain pres－sure after tumor resection，intraoperative ultrasonography or immediate review of CT should be performed in time to assist the diagno－sis so as not to delay the condition and cause unnecessary damage.