Objective：To explore the clinical characteristics and high-risk factors of intestinal necrosis in infants with incarcerated in－guinal hernia. Methods：This retrospective study enrolled 246 infants of incarcerated inguinal hernia at Children’s Hospital of Chongqing Medical University from January 2013 to January 2017. The clinical characteristics were studied and the high-risk factors of intestinal necrosis were identified by univariate analysis and mutivariate logistic regression analysis. Results：The overrall rate of intestinal necrosis was 10.2%（25/246）. Multivariate analysis showed that C-reactive protein（CRP）＞8 mg/L was the independent risk factor of intestinal necrosis in infants with incarcerated inguinal hernia. The ROC analysis showed that in the diagnosis of intestinal necrosis，CRP had a high sensitivity（80.0%） and specificity（93.7%），AUC ROC of 0.868（95%CI=0.820-0.908）. Conclusion：The clinical manifestation of incarcerated inguinal hernia in infants is atypical and incarcerated inguinal hernia in young infants can leads to intestinal necrosis easily. CRP has a good value in diagnosis of intestinal necrosis in infants with incarcerated inguinal hernia.